| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gnb1l | pih1d1 | ENSDARP00000052711 | ENSDARP00000055307 | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity); Belongs to the PIH1 family. | 0.448 |
| gnb1l | ruvbl1 | ENSDARP00000052711 | ENSDARP00000012488 | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family. | 0.672 |
| gnb1l | ruvbl2 | ENSDARP00000052711 | ENSDARP00000072482 | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] | 0.615 |
| gnb1l | telo2 | ENSDARP00000052711 | ENSDARP00000114983 | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity); Belongs to the TEL2 family. | 0.788 |
| gnb1l | trrap | ENSDARP00000052711 | ENSDARP00000137625 | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. | 0.521 |
| gnb1l | tti1 | ENSDARP00000052711 | ENSDARP00000019450 | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | TELO2-interacting protein 1. | 0.910 |
| mlst8 | mtor | ENSDARP00000118004 | ENSDARP00000105458 | Target of rapamycin complex subunit lst8. | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | 0.999 |
| mlst8 | smg1 | ENSDARP00000118004 | ENSDARP00000071267 | Target of rapamycin complex subunit lst8. | SMG1 homolog phosphatidylinositol 3-kinase-related kinase (C. elegans); Belongs to the PI3/PI4-kinase family. | 0.942 |
| mlst8 | telo2 | ENSDARP00000118004 | ENSDARP00000114983 | Target of rapamycin complex subunit lst8. | Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity); Belongs to the TEL2 family. | 0.717 |
| mlst8 | tti1 | ENSDARP00000118004 | ENSDARP00000019450 | Target of rapamycin complex subunit lst8. | TELO2-interacting protein 1. | 0.936 |
| mtor | mlst8 | ENSDARP00000105458 | ENSDARP00000118004 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | Target of rapamycin complex subunit lst8. | 0.999 |
| mtor | ruvbl1 | ENSDARP00000105458 | ENSDARP00000012488 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family. | 0.951 |
| mtor | ruvbl2 | ENSDARP00000105458 | ENSDARP00000072482 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] | 0.936 |
| mtor | smg1 | ENSDARP00000105458 | ENSDARP00000071267 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | SMG1 homolog phosphatidylinositol 3-kinase-related kinase (C. elegans); Belongs to the PI3/PI4-kinase family. | 0.577 |
| mtor | telo2 | ENSDARP00000105458 | ENSDARP00000114983 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity); Belongs to the TEL2 family. | 0.998 |
| mtor | trrap | ENSDARP00000105458 | ENSDARP00000137625 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. | 0.646 |
| mtor | tti1 | ENSDARP00000105458 | ENSDARP00000019450 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. | TELO2-interacting protein 1. | 0.999 |
| pih1d1 | gnb1l | ENSDARP00000055307 | ENSDARP00000052711 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity); Belongs to the PIH1 family. | Guanine nucleotide-binding protein (G protein), beta polypeptide 1-like. | 0.448 |
| pih1d1 | ruvbl1 | ENSDARP00000055307 | ENSDARP00000012488 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity); Belongs to the PIH1 family. | RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family. | 0.999 |
| pih1d1 | ruvbl2 | ENSDARP00000055307 | ENSDARP00000072482 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity); Belongs to the PIH1 family. | RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] | 0.999 |
