Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
p2rx3aP2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (410 aa)    
Predicted Functional Partners:
trpa1b
Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.763
LOC101885757
Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
      
 0.596
adam19b
ADAM metallopeptidase domain 19b.
   
  
 0.576
ccr12a
Chemokine (C-C motif) receptor 12a; Belongs to the G-protein coupled receptor 1 family.
      
 0.557
panx1b
Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.
      
 0.547
p2rx7
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
  
0.534
panx1a
Pannexin; Structural component of the gap junctions and the hemichannels.
      
 0.463
CALHM1
Si:dkeyp-80c12.5.
      
 0.463
p2rx2
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
    
 0.454
asic1a
Acid-sensing ion channel 1A; Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.
      
 0.443
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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