Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
tbr1bT-box brain transcription factor 1b. (676 aa)    
Predicted Functional Partners:
satb2
DNA-binding protein SATB.
   
 
 0.890
pax6a
Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family.
   
 
 0.839
foxg1a
Forkhead box G1a.
   
  
 0.799
emx3
Empty spiracles homeobox 3.
   
 
 0.792
Reln
Reelin domain-containing protein.
    
 
 0.792
fezf2
Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons.
   
 
 0.788
dlx1a
Homeobox protein Dlx1a.
   
 
 0.764
dlx2a
Homeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family.
   
 
 0.740
emx1
Homeobox protein EMX1; May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system; Belongs to the EMX homeobox family.
   
 
 0.735
zic1
ZIC family member 1 (Odd-paired homolog, Drosophila).
   
 
 0.708
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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