Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
foxg1bForkhead box G1b. (341 aa)    
Predicted Functional Partners:
mical3a
Protein-methionine sulfoxide oxidase mical3a; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family.
      
 0.719
kidins220a
Kinase D-interacting substrate 220a.
    
 0.638
foxn4
Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...]
   
    0.637
nkx2.4a
NK2 homeobox 4a.
   
 
 0.629
lim2.4
Lens intrinsic membrane protein 2.4.
   
  
 0.622
Q1L949_DANRE
Si:ch211-250g4.3.
    
 
 0.608
otx5
Orthodenticle homolog 5.
   
  
 0.604
ankrd12
Ankyrin repeat domain 12.
    
 0.574
pik3r3a
Phosphoinositide-3-kinase, regulatory subunit 3a (gamma).
      
 0.555
ppm1h
Protein phosphatase 1H.
      
 0.546
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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