Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pak4Non-specific serine/threonine protein kinase. (664 aa)    
Predicted Functional Partners:
cdc42
Cell division cycle 42.
   
 0.986
cdc42l
Cell division cycle 42,-like.
   
 0.973
cdc42l2
Cell division cycle 42-like 2.
   
 0.969
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.
    
 0.968
rac2
Rac family small GTPase 2.
   
 0.964
limk1a
LIM domain kinase 1a.
    
0.963
limk2
LIM domain kinase 2.
   
0.960
limk1b
LIM domain kinase 1b.
    
0.959
nck2b
Cytoplasmic protein.
    
 0.952
map2k1
Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.
    
 0.949
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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