Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ankrd46bAnkyrin repeat domain-containing protein 46. (228 aa)    
Predicted Functional Partners:
mgrn1b
Mahogunin, ring finger 1b.
    
   0.967
dip2ca
Disco-interacting protein 2 homolog Ca.
    
 0.740
g2e3
G2/M-phase-specific E3 ubiquitin protein ligase.
    
 0.730
mgrn1a
Probable E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Acts also as a negative regulator of hedgehog signaling.
    
   0.726
gng7
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
      
 0.720
cul2
Cullin 2; Belongs to the cullin family.
    
 
 0.710
htr2cl1
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1.
    
 
 0.698
cars2
Cysteinyl-tRNA synthetase 2, mitochondrial.
    
 
 0.691
snx13
Sorting nexin 13.
    
 
 0.642
RNF157
Si:dkey-49c17.3.
    
   0.627
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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