Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
kcnj2aPotassium inwardly rectifying channel subfamily J member 2a. (427 aa)    
Predicted Functional Partners:
kcnq1.1
Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.
   
 
 0.967
kcnh6a
Potassium voltage-gated channel, subfamily H (eag-related), member 6a.
      
 0.888
kcnh2a
Potassium voltage-gated channel, subfamily H (eag-related), member 2a.
      
 0.887
cx43
Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily.
    
 
 0.824
kcnj4
Uncharacterized protein.
  
  
0.823
hcn4
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
      
 0.819
kcnj14
Potassium inwardly rectifying channel subfamily J member 14.
  
  
0.819
ryr2b
Ryanodine receptor 2b (cardiac).
      
 0.759
kcnd3
Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.
   
 
 0.755
cacna1c
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
    
 
 0.727
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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