Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
malt2MALT paracaspase 2. (806 aa)    
Predicted Functional Partners:
card9
Caspase recruitment domain family, member 9.
   
 0.986
card11
Caspase recruitment domain family, member 11.
    
 0.981
chuk
Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
   
 0.963
casp8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 0.963
ikbkb
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 0.961
ikbkg
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.952
bcl10
BCL10 immune-signaling adaptor.
     
 0.951
casp10
Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
  0.947
mapk13
Mitogen-activated protein kinase.
    
  0.946
mapk9
Mitogen-activated protein kinase.
    
  0.945
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.