Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dnase1Deoxyribonuclease; Belongs to the DNase I family. (278 aa)    
Predicted Functional Partners:
pla2g1b
Phospholipase A(2).
   
    0.639
slc25a21
Solute carrier family 25 member 21; Belongs to the mitochondrial carrier (TC 2.A.29) family.
    
   0.635
phf13
PHD finger protein 13.
    
   0.635
tbx20
T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.
    
   0.630
nudt12
Nudix (nucleoside diphosphate-linked moiety X)-type motif 12.
    
 0.621
trpm2
Transient receptor potential cation channel subfamily M member 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
     
  0.606
spcs2
Probable signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
    
 
 0.598
spcs1
Signal peptidase complex subunit 1 homolog (S. cerevisiae).
    
   0.582
wipf1b
WAS/WASL-interacting protein family, member 1b.
    
   0.555
wipf1a
WAS/WASL-interacting protein family, member 1a.
    
   0.555
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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