shbg protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

shbg

Sex hormone-binding globulin. (381 aa)

Predicted Functional Partners:

nrxn2a

0.686

nrxn1a

0.685

amh

0.678

nrxn3a

0.671

crp3

0.649

ins

0.645

cyp19a1a

0.638

esr1

0.636

adipoqb

0.631

prl2

0.601

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
adipoqb	ins	ENSDARP00000141357	ENSDARP00000051221	Adiponectin, C1Q and collagen domain-containing, b.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.783
adipoqb	shbg	ENSDARP00000141357	ENSDARP00000020485	Adiponectin, C1Q and collagen domain-containing, b.	Sex hormone-binding globulin.	0.631
amh	cyp19a1a	ENSDARP00000015395	ENSDARP00000111604	Anti-Mullerian hormone.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.991
amh	esr1	ENSDARP00000015395	ENSDARP00000082277	Anti-Mullerian hormone.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.666
amh	ins	ENSDARP00000015395	ENSDARP00000051221	Anti-Mullerian hormone.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.526
amh	prl2	ENSDARP00000015395	ENSDARP00000114109	Anti-Mullerian hormone.	Prolactin 2.	0.454
amh	shbg	ENSDARP00000015395	ENSDARP00000020485	Anti-Mullerian hormone.	Sex hormone-binding globulin.	0.678
crp3	nrxn1a	ENSDARP00000104927	ENSDARP00000082592	Pentaxin.	Neurexin-1a-beta; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in formation or maintenance of synaptic junctions; Belongs to the neurexin family.	0.561
crp3	nrxn2a	ENSDARP00000104927	ENSDARP00000118463	Pentaxin.	Neurexin 2a.	0.563
crp3	nrxn3a	ENSDARP00000104927	ENSDARP00000127605	Pentaxin.	Neurexin-3a.	0.571
crp3	shbg	ENSDARP00000104927	ENSDARP00000020485	Pentaxin.	Sex hormone-binding globulin.	0.649
cyp19a1a	amh	ENSDARP00000111604	ENSDARP00000015395	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Anti-Mullerian hormone.	0.991
cyp19a1a	esr1	ENSDARP00000111604	ENSDARP00000082277	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.985
cyp19a1a	ins	ENSDARP00000111604	ENSDARP00000051221	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.573
cyp19a1a	prl2	ENSDARP00000111604	ENSDARP00000114109	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Prolactin 2.	0.523
cyp19a1a	shbg	ENSDARP00000111604	ENSDARP00000020485	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Sex hormone-binding globulin.	0.638
esr1	amh	ENSDARP00000082277	ENSDARP00000015395	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Anti-Mullerian hormone.	0.666
esr1	cyp19a1a	ENSDARP00000082277	ENSDARP00000111604	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.985
esr1	ins	ENSDARP00000082277	ENSDARP00000051221	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.766
esr1	prl2	ENSDARP00000082277	ENSDARP00000114109	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Prolactin 2.	0.598

page 1 of 3

Server load: low (26%) [HD]

Permalink

Network

Fusion

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Neighborhood

© STRING Consortium 2026

Credits

Access

Info

About