htra1b protein (Danio rerio) - STRING interaction network

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htra1b

Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] (476 aa)

Predicted Functional Partners:

acana

0.750

tspan13a

0.600

lmod1b

0.595

rerglb

0.594

cfb

0.584

xiap

0.578

cfbl

0.566

neurl2

0.563

pink1

0.560

pla2g12a

0.560

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acana	htra1b	ENSDARP00000024325	ENSDARP00000020528	Aggrecan a.	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	0.750
cfb	cfbl	ENSDARP00000072059	ENSDARP00000091557	Complement factor B; Belongs to the peptidase S1 family.	Complement factor b,-like; Belongs to the peptidase S1 family.	0.413
cfb	htra1b	ENSDARP00000072059	ENSDARP00000020528	Complement factor B; Belongs to the peptidase S1 family.	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	0.584
cfbl	cfb	ENSDARP00000091557	ENSDARP00000072059	Complement factor b,-like; Belongs to the peptidase S1 family.	Complement factor B; Belongs to the peptidase S1 family.	0.413
cfbl	htra1b	ENSDARP00000091557	ENSDARP00000020528	Complement factor b,-like; Belongs to the peptidase S1 family.	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	0.566
htra1b	acana	ENSDARP00000020528	ENSDARP00000024325	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Aggrecan a.	0.750
htra1b	cfb	ENSDARP00000020528	ENSDARP00000072059	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Complement factor B; Belongs to the peptidase S1 family.	0.584
htra1b	cfbl	ENSDARP00000020528	ENSDARP00000091557	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Complement factor b,-like; Belongs to the peptidase S1 family.	0.566
htra1b	lmod1b	ENSDARP00000020528	ENSDARP00000104330	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Leiomodin 1b (smooth muscle).	0.595
htra1b	neurl2	ENSDARP00000020528	ENSDARP00000084765	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Neuralized E3 ubiquitin protein ligase 2.	0.563
htra1b	pink1	ENSDARP00000020528	ENSDARP00000014981	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	PTEN-induced kinase 1.	0.560
htra1b	pla2g12a	ENSDARP00000020528	ENSDARP00000094182	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Phospholipase A2, group XIIA.	0.560
htra1b	rerglb	ENSDARP00000020528	ENSDARP00000070974	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Tripartite motif-containing 66.	0.594
htra1b	tspan13a	ENSDARP00000020528	ENSDARP00000090549	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	Zgc:91858 protein; Belongs to the tetraspanin (TM4SF) family.	0.600
htra1b	xiap	ENSDARP00000020528	ENSDARP00000018322	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	X-linked inhibitor of apoptosis.	0.578
lmod1b	htra1b	ENSDARP00000104330	ENSDARP00000020528	Leiomodin 1b (smooth muscle).	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	0.595
neurl2	htra1b	ENSDARP00000084765	ENSDARP00000020528	Neuralized E3 ubiquitin protein ligase 2.	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	0.563
neurl2	pla2g12a	ENSDARP00000084765	ENSDARP00000094182	Neuralized E3 ubiquitin protein ligase 2.	Phospholipase A2, group XIIA.	0.661
neurl2	tspan13a	ENSDARP00000084765	ENSDARP00000090549	Neuralized E3 ubiquitin protein ligase 2.	Zgc:91858 protein; Belongs to the tetraspanin (TM4SF) family.	0.720
pink1	htra1b	ENSDARP00000014981	ENSDARP00000020528	PTEN-induced kinase 1.	Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]	0.560

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