STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)    
Predicted Functional Partners:
gsr
Glutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 0.997
gss
Glutathione synthetase.
   
 
 0.951
alox5a
Arachidonate 5-lipoxygenase a.
     
 0.923
gstp1
Pi-class glutathione S-transferase; Belongs to the GST superfamily.
   
 
 0.922
sod1
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
   
 0.918
chac1
Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Not [...]
   
 
 0.903
chac2
Putative glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
     
 0.902
cyp2p7
Cytochrome P450, family 2, subfamily J, polypeptide 24; Belongs to the cytochrome P450 family.
   
 
  0.901
cyp2p8
Cytochrome P450, family 2, subfamily J, polypeptide 23; Belongs to the cytochrome P450 family.
   
 
  0.901
cyp2j20
Cytochrome P450, family 2, subfamily J, polypeptide 20; Belongs to the cytochrome P450 family.
   
 
  0.901
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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