optn protein (Danio rerio) - STRING interaction network

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[Homology]

Score

optn

Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. (517 aa)

Predicted Functional Partners:

tbk1

0.989

sqstm1

0.958

map1lc3b

0.938

rps27a

0.936

uba52

0.935

chuk

0.933

ikbkb

0.933

ikbke

0.928

tax1bp1b

0.921

calcoco2

0.919

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
calcoco2	chuk	ENSDARP00000127186	ENSDARP00000013115	Calcium-binding and coiled-coil domain 2.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.464
calcoco2	ikbkb	ENSDARP00000127186	ENSDARP00000117685	Calcium-binding and coiled-coil domain 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.464
calcoco2	ikbke	ENSDARP00000127186	ENSDARP00000074566	Calcium-binding and coiled-coil domain 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.851
calcoco2	map1lc3b	ENSDARP00000127186	ENSDARP00000130443	Calcium-binding and coiled-coil domain 2.	Microtubule-associated protein 1 light chain 3 beta.	0.900
calcoco2	optn	ENSDARP00000127186	ENSDARP00000020714	Calcium-binding and coiled-coil domain 2.	Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.	0.919
calcoco2	rps27a	ENSDARP00000127186	ENSDARP00000128775	Calcium-binding and coiled-coil domain 2.	Ribosomal protein S27a.	0.944
calcoco2	sqstm1	ENSDARP00000127186	ENSDARP00000117113	Calcium-binding and coiled-coil domain 2.	Sequestosome 1.	0.971
calcoco2	tax1bp1b	ENSDARP00000127186	ENSDARP00000040726	Calcium-binding and coiled-coil domain 2.	Tax1-binding protein 1 homolog B; May have anti-apoptotic activity.	0.942
calcoco2	tbk1	ENSDARP00000127186	ENSDARP00000132718	Calcium-binding and coiled-coil domain 2.	TANK-binding kinase 1.	0.944
calcoco2	uba52	ENSDARP00000127186	ENSDARP00000060744	Calcium-binding and coiled-coil domain 2.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.944
chuk	calcoco2	ENSDARP00000013115	ENSDARP00000127186	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Calcium-binding and coiled-coil domain 2.	0.464
chuk	ikbkb	ENSDARP00000013115	ENSDARP00000117685	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.994
chuk	optn	ENSDARP00000013115	ENSDARP00000020714	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.	0.933
chuk	rps27a	ENSDARP00000013115	ENSDARP00000128775	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Ribosomal protein S27a.	0.503
chuk	sqstm1	ENSDARP00000013115	ENSDARP00000117113	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Sequestosome 1.	0.489
chuk	tax1bp1b	ENSDARP00000013115	ENSDARP00000040726	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Tax1-binding protein 1 homolog B; May have anti-apoptotic activity.	0.532
chuk	tbk1	ENSDARP00000013115	ENSDARP00000132718	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TANK-binding kinase 1.	0.494
chuk	uba52	ENSDARP00000013115	ENSDARP00000060744	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.482
ikbkb	calcoco2	ENSDARP00000117685	ENSDARP00000127186	Inhibitor of nuclear factor kappa B kinase subunit beta.	Calcium-binding and coiled-coil domain 2.	0.464
ikbkb	chuk	ENSDARP00000117685	ENSDARP00000013115	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.994

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