Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
vps50-2VPS50 EARP/GARPII complex subunit. (314 aa)    
Predicted Functional Partners:
vps51
Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling (By similarity).
    
 0.988
vps53
VPS53 subunit of GARP complex.
   
 
 0.984
vps54
VPS54 subunit of GARP complex.
    
 
 0.983
vps52
VPS52 subunit of GARP complex.
   
 
 0.981
eipr1
EARP-interacting protein homolog; Belongs to the WD repeat EIPR1 family.
    
 
 0.946
ralgps1
Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor. May be involved in cytoskeletal organization.
      
 0.794
snap29
Synaptosome-associated protein 29.
    
 
 0.775
LOC100149241
Transmembrane channel-like protein.
      
 0.720
arfrp1
ADP-ribosylation factor-related protein 1.
      
 0.690
TOM1L2
Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family.
      
 0.670
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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