Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)    
Predicted Functional Partners:
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.999
cdk1
Cell division control protein 2; Belongs to the protein kinase superfamily.
   
 0.999
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.998
e2f1
E2F transcription factor 1.
   
 0.996
fzr1a
Fizzy/cell division cycle 20 related 1 (Drosophila).
   
 0.995
rb1
Retinoblastoma 1.
   
 0.993
e2f3
E2F transcription factor 3.
   
 0.991
cdkn1a
Cyclin-dependent kinase inhibitor 1A.
   
 0.989
cdc20
Cell division cycle 20 homolog.
   
 0.988
fzr1b
Fizzy/cell division cycle 20-related 1b.
   
 0.986
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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