node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
barhl2 | bhlhe22 | ENSDARP00000137279 | ENSDARP00000113648 | BarH-class homeodomain transcription factor. | Basic helix-loop-helix family, member e22. | 0.856 |
barhl2 | foxn4 | ENSDARP00000137279 | ENSDARP00000020367 | BarH-class homeodomain transcription factor. | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | 0.875 |
barhl2 | lhx1a | ENSDARP00000137279 | ENSDARP00000021069 | BarH-class homeodomain transcription factor. | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | 0.695 |
barhl2 | pax2a | ENSDARP00000137279 | ENSDARP00000071466 | BarH-class homeodomain transcription factor. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.508 |
barhl2 | ptf1a | ENSDARP00000137279 | ENSDARP00000011265 | BarH-class homeodomain transcription factor. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.826 |
bhlhe22 | barhl2 | ENSDARP00000113648 | ENSDARP00000137279 | Basic helix-loop-helix family, member e22. | BarH-class homeodomain transcription factor. | 0.856 |
bhlhe22 | foxn4 | ENSDARP00000113648 | ENSDARP00000020367 | Basic helix-loop-helix family, member e22. | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | 0.764 |
bhlhe22 | lhx1a | ENSDARP00000113648 | ENSDARP00000021069 | Basic helix-loop-helix family, member e22. | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | 0.702 |
bhlhe22 | pax2a | ENSDARP00000113648 | ENSDARP00000071466 | Basic helix-loop-helix family, member e22. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.478 |
bhlhe22 | pax6a | ENSDARP00000113648 | ENSDARP00000135767 | Basic helix-loop-helix family, member e22. | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. | 0.681 |
bhlhe22 | ptf1a | ENSDARP00000113648 | ENSDARP00000011265 | Basic helix-loop-helix family, member e22. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.721 |
ccnk | lhx1a | ENSDARP00000113893 | ENSDARP00000021069 | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | 0.786 |
foxn4 | barhl2 | ENSDARP00000020367 | ENSDARP00000137279 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | BarH-class homeodomain transcription factor. | 0.875 |
foxn4 | bhlhe22 | ENSDARP00000020367 | ENSDARP00000113648 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | Basic helix-loop-helix family, member e22. | 0.764 |
foxn4 | lhx1a | ENSDARP00000020367 | ENSDARP00000021069 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | 0.701 |
foxn4 | pax6a | ENSDARP00000020367 | ENSDARP00000135767 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. | 0.621 |
foxn4 | ptf1a | ENSDARP00000020367 | ENSDARP00000011265 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.840 |
lhx1a | barhl2 | ENSDARP00000021069 | ENSDARP00000137279 | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | BarH-class homeodomain transcription factor. | 0.695 |
lhx1a | bhlhe22 | ENSDARP00000021069 | ENSDARP00000113648 | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | Basic helix-loop-helix family, member e22. | 0.702 |
lhx1a | ccnk | ENSDARP00000021069 | ENSDARP00000113893 | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). | 0.786 |