Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nedd8NEDD8 ubiquitin-like modifier. (89 aa)    
Predicted Functional Partners:
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
   
 0.996
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
 0.991
uba3
NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
    
 0.989
senp8
SUMO peptidase family member, NEDD8-specific.
    
 0.984
cul2
Cullin 2; Belongs to the cullin family.
    
 0.981
cul3b
Cullin 3b; Belongs to the cullin family.
    
 0.981
ddb1
Damage-specific DNA-binding protein 1.
    
 0.977
cops5
COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...]
   
 0.975
cul1a
Cullin 1a; Belongs to the cullin family.
    
 0.973
UBE2M
Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.973
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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