Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
slc22a4Solute carrier family 22 member 4. (553 aa)    
Predicted Functional Partners:
slc25a39
Solute carrier family 25 member 39; May be involved in the early steps of heme biosynthesis or in the regulation of delta-aminolevulinic acid synthase function.
      
 0.781
tmem14ca
Transmembrane protein 14C; Required for normal heme biosynthesis.
      
 0.780
slc22a2
Solute carrier family 22 member 2.
  
0.756
isca1
Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family.
      
 0.734
oct2
Organic cation transporter 2.
  
 
0.728
slc5a7a
Solute carrier family 5 member 7a; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
     
 0.676
SLC5A7
Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
     
 0.676
slc44a1a
Solute carrier family 44 member 1a; Belongs to the CTL (choline transporter-like) family.
     
 0.672
slc44a1b
Solute carrier family 44 member 1b; Belongs to the CTL (choline transporter-like) family.
     
 0.672
gramd2aa
GRAM domain-containing 2Aa.
      
 0.594
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.