| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| axin1 | axin2 | ENSDARP00000135613 | ENSDARP00000132477 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | 0.995 |
| axin1 | dvl2 | ENSDARP00000135613 | ENSDARP00000021237 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Dishevelled segment polarity protein 2. | 0.996 |
| axin1 | fzd2 | ENSDARP00000135613 | ENSDARP00000071107 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.850 |
| axin1 | prickle1a | ENSDARP00000135613 | ENSDARP00000059513 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Prickle homolog 1a. | 0.471 |
| axin1 | prickle1b | ENSDARP00000135613 | ENSDARP00000118988 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Prickle homolog 1b. | 0.423 |
| axin1 | prickle2a | ENSDARP00000135613 | ENSDARP00000012600 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Prickle homolog 2a. | 0.425 |
| axin1 | prickle2b | ENSDARP00000135613 | ENSDARP00000135945 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Prickle homolog 2b. | 0.490 |
| axin1 | vangl1 | ENSDARP00000135613 | ENSDARP00000028523 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Vang-like protein. | 0.435 |
| axin1 | vangl2 | ENSDARP00000135613 | ENSDARP00000031546 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] | 0.484 |
| axin2 | axin1 | ENSDARP00000132477 | ENSDARP00000135613 | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | 0.995 |
| axin2 | dvl2 | ENSDARP00000132477 | ENSDARP00000021237 | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | Dishevelled segment polarity protein 2. | 0.991 |
| axin2 | fzd2 | ENSDARP00000132477 | ENSDARP00000071107 | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.608 |
| axin2 | fzd6 | ENSDARP00000132477 | ENSDARP00000140294 | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.542 |
| dvl2 | axin1 | ENSDARP00000021237 | ENSDARP00000135613 | Dishevelled segment polarity protein 2. | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | 0.996 |
| dvl2 | axin2 | ENSDARP00000021237 | ENSDARP00000132477 | Dishevelled segment polarity protein 2. | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. | 0.991 |
| dvl2 | fzd2 | ENSDARP00000021237 | ENSDARP00000071107 | Dishevelled segment polarity protein 2. | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.992 |
| dvl2 | fzd6 | ENSDARP00000021237 | ENSDARP00000140294 | Dishevelled segment polarity protein 2. | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.994 |
| dvl2 | prickle1a | ENSDARP00000021237 | ENSDARP00000059513 | Dishevelled segment polarity protein 2. | Prickle homolog 1a. | 0.993 |
| dvl2 | prickle1b | ENSDARP00000021237 | ENSDARP00000118988 | Dishevelled segment polarity protein 2. | Prickle homolog 1b. | 0.995 |
| dvl2 | prickle2a | ENSDARP00000021237 | ENSDARP00000012600 | Dishevelled segment polarity protein 2. | Prickle homolog 2a. | 0.992 |
