STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
epas1aEndothelial PAS domain protein 1a. (842 aa)    
Predicted Functional Partners:
arnt
Aryl hydrocarbon receptor nuclear translocator.
   
 
0.807
emilin3a
Elastin microfibril interfacer 3a.
      
 0.693
hif1an
Hypoxia-inducible factor 1-alpha inhibitor; Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins.
    
 
 0.684
egln3
Egl-9 family hypoxia-inducible factor 3.
    
 
 0.673
ccndx
Cyclin Dx; Belongs to the cyclin family.
      
 0.656
arnt2
Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor.
   
 
0.656
aco1
Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.
   
  
 0.642
vhl
Von Hippel-Lindau tumor suppressor.
    
 
 0.625
vhll
Von Hippel-Lindau tumor suppressor-like.
    
 
 0.625
eif4e2
Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family.
    
 
 0.585
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.