STRINGSTRING
pdcd10b protein (Danio rerio) - STRING interaction network
"pdcd10b" - Programmed cell death 10b in Danio rerio
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pdcd10bProgrammed cell death 10b; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development (210 aa)    
Predicted Functional Partners:
zgc:175288
Zgc-175288 (412 aa)
     
 
  0.969
ccm2
Cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity) (455 aa)
       
 
  0.914
stk24a
Serine/threonine kinase 24a (STE20 homolog, yeast) (415 aa)
     
 
  0.886
stk24b
Serine/threonine kinase 24b (STE20 homolog, yeast) (420 aa)
     
 
  0.886
stk25b
Serine/threonine kinase 25b (424 aa)
     
 
  0.886
krit1
KRIT1, ankyrin repeat containing; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from prol [...] (741 aa)
     
 
  0.773
LPXN
Leupaxin (416 aa)
       
      0.763
ENSDARG00000086858
Paxillin (276 aa)
       
      0.763
pxn
Paxillin (282 aa)
       
      0.763
LOC565130
Paxillin (1197 aa)
       
      0.763
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio, Brachydanio rerio, Brachydanio rerio frankei, Celestichthys, Cyprinidae, Cypriniformes, Cypriniphysi, Cyprinoidea, Cyprinoidei, Cyprinus rerio, D. rerio, Danio, Danio frankei, Danio rerio, Danio rerio frankei, Ostariophysi, Otocephala, Otophysi, leopard danio, zebra danio, zebra fish, zebrafish
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