Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
limk1bLIM domain kinase 1b. (615 aa)    
Predicted Functional Partners:
cfl1l
Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family.
   
 0.990
cfl2
Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.
   
 0.990
cfl1
Muscle cofilin 2; Belongs to the actin-binding proteins ADF family.
   
 0.990
rock2a
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
    
 0.963
rock1
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
    
 0.963
pak4
Non-specific serine/threonine protein kinase.
    
0.959
pak1
Non-specific serine/threonine protein kinase.
    
 0.955
LOC100536197
Non-specific serine/threonine protein kinase.
    
 0.952
pak6b
Non-specific serine/threonine protein kinase.
    
 0.952
pak7
P21 protein (Cdc42/Rac)-activated kinase 7.
    
 0.952
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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