Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
epha3Ephrin type-A receptor 3. (963 aa)    
Predicted Functional Partners:
ENSDARP00000152912
Si:dkey-246i14.3; Belongs to the ephrin family.
   
 0.927
efna1b
Ephrin A-L1; Belongs to the ephrin family.
   
 0.910
efna5b
Ephrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...]
   
 0.910
efna1a
Ephrin-A1a; Belongs to the ephrin family.
   
 0.908
efna2a
Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling thro [...]
   
 0.905
efna2b
Ephrin-A2b; Belongs to the ephrin family.
   
 0.903
efna3a
Ephrin-A3a; Belongs to the ephrin family.
   
 0.901
efna3b
Ephrin-A3b; Belongs to the ephrin family.
   
 0.900
efnb1
Ephrin-B1; Belongs to the ephrin family.
   
 0.822
efnb2b
Ephrin-B2b; Belongs to the ephrin family.
   
 0.766
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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