Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mob3aMOB kinase activator 3A. (216 aa)    
Predicted Functional Partners:
stk3
Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...]
   
 
 0.796
mob4
MOB1, Mps One Binder kinase activator-like 3 (Yeast).
   
  
0.566
C13H9orf72
Zgc:100846.
      
 0.532
nop16
Nucleolar protein 16.
      
 0.521
CR021_DANRE
UPF0711 protein C18orf21 homolog; Belongs to the UPF0711 family.
    
 
 0.506
tbck
TBC1 domain-containing kinase.
      
 0.493
naa20
N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
      
 0.491
dph5
Diphthamide biosynthesis 5.
      
 0.488
lats2
Large tumor suppressor kinase 2.
    
 
 0.477
nepro
Nucleolus and neural progenitor protein; May play a role in the Notch signaling pathway. Belongs to the nepro family.
    
 
 0.472
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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