Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ufl1E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (793 aa)    
Predicted Functional Partners:
ufc1
Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage.
   
 
 0.998
cdk5rap3
CDK5 regulatory subunit-associated protein 3.
   
 
 0.997
ddrgk1
DDRGK domain-containing protein 1; By regulating the post-translational modification of specific proteins, may play a role in different cellular process (By similarity). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator.
   
 
 0.996
ufm1
Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family.
   
 
 0.994
uba5
Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2.
   
  
 0.965
ufsp2
Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins; Belongs to the peptidase C78 family.
   
  
 0.952
srprb
SRP receptor subunit beta.
   
  
 0.822
rpl26
ATPase H+ transporting V0 subunit e1.
    
 
 0.819
eif6
Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
    
 
 0.764
LTN1
Si:dkey-175g6.5.
   
 
 0.763
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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