Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MCUR1Zgc:165532. (258 aa)    
Predicted Functional Partners:
micu1
Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. micu1 and micu2 form a disulfide-linked heterodimer that stimulates and inhibits mcu activity, depending on the concentration of calcium. Micu1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of mcu at low concentration of calcium, preventing channel opening. Enhances mcu opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm.
      
 0.993
mcu
Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by micu1 and micu2. At low Ca(2+) levels mcu activity is down-regulated by micu1 and micu2; at higher Ca(2+) levels micu1 increases mcu activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffe [...]
    
 
 0.984
letm1
Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity).
    
 
 0.742
micu3b
Mitochondrial calcium uptake family, member 3b.
      
 0.738
micu3a
Mitochondrial calcium uptake family, member 3a.
      
 0.735
smdt1a
Single-pass membrane protein with aspartate-rich tail 1a.
      
 0.720
vdac2
Voltage-dependent anion channel 2.
      
 0.572
slc8b1
Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.531
atp2a1
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
      
 0.501
vdac3
Voltage-dependent anion channel 3.
      
 0.461
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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