Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
isoc2Isochorismatase domain-containing protein 2; Belongs to the isochorismatase family. (197 aa)    
Predicted Functional Partners:
mblac2
Metallo-beta-lactamase domain-containing 2.
  
 
 0.959
tmem86b
Transmembrane protein 86B.
      
 0.920
es1
ES1 protein, mitochondrial; Plays a role in promoting mitochondrial enlargement in cone photoreceptor cells in a fusion-independent and ATP-dependent manner.
   
  
 0.884
nit2
Omega-amidase NIT2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha- ketoglutarate and oxaloacetate, respectively.
  
 
 0.865
gatd3a
Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial.
   
  
 0.825
naprt
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family.
  
 
 0.756
oplah
5-oxoprolinase, ATP-hydrolysing.
    
 0.622
tmem86a
Transmembrane protein 86A.
      
 0.590
tgfbrap1
Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family.
    
   0.580
arg2
Arginase.
  
 
 0.572
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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