Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Experiments
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[Homology]
Score
grk6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (575 aa)    
Predicted Functional Partners:
arrb1
Arrestin, beta 1.
    
 0.959
smo
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.933
arrb2a
Arrestin, beta 2a.
    
 0.932
cxcr4b
Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family.
    
  0.873
cxcr4a
Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family.
    
  0.873
cxcr2
Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.
    
  0.872
arrb2b
Arrestin, beta 2b.
    
 0.869
csnk1a1
Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.
     
 0.823
cxcr1
Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.
    
  0.819
ccr11.1
Chemokine (C-C motif) receptor 11.1; Belongs to the G-protein coupled receptor 1 family.
    
  0.814
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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