Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mcm6DNA helicase; Belongs to the MCM family. (830 aa)    
Predicted Functional Partners:
mcm3
DNA helicase; Belongs to the MCM family.
   
0.999
mcm5
DNA helicase; Belongs to the MCM family.
   
0.999
mcm3l
DNA helicase; Belongs to the MCM family.
   
0.999
mcm4
DNA helicase; Belongs to the MCM family.
   
0.999
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.999
cdt1
Chromatin licensing and DNA replication factor 1.
   
 0.999
mcmbp
Mini-chromosome maintenance complex-binding protein; Associated component of the mcm complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the mcm complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the mcm complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the mcm complex. Required for sister chromatid cohesion (By similarity).
   
 0.999
mcm7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
0.999
mcm2
DNA helicase; Belongs to the MCM family.
   
0.999
mcm10
Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).
   
 0.998
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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