Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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chd1lChromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP- dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity); Belongs to the SNF2/RAD54 helicase family. (1026 aa)    
Predicted Functional Partners:
parp1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 0.990
Zgc:165656
Zgc:165656.
    
 
 0.972
xrcc1
X-ray repair-complementing defective repair in Chinese hamster cells 1.
    
 
 0.968
rnf146
E3 ubiquitin-protein ligase rnf146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
    
 
 0.967
supt16h
SPT16 homolog, facilitates chromatin-remodeling subunit.
   
 
 0.944
parp2
Poly [ADP-ribose] polymerase.
    
 
 0.937
xrcc6
X-ray repair-complementing defective repair in Chinese hamster cells 6.
   
 
 0.935
hltf
Helicase-like transcription factor.
  
 
0.922
xpc
Xeroderma pigmentosum, complementation group C.
   
 0.899
pole3
Polymerase (DNA directed), epsilon 3 (p17 subunit).
    
 0.867
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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