Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
anp32aAcidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. (254 aa)    
Predicted Functional Partners:
setb
SET nuclear proto-oncogene b; Belongs to the nucleosome assembly protein (NAP) family.
   
 0.948
ptmab
Prothymosin alpha-B.
   
 
 0.876
ptmaa
Prothymosin alpha-A.
   
 
 0.855
xpo1b
Exportin 1 (CRM1 homolog, yeast) b.
   
 0.828
dmap1
DNA methyltransferase 1-associated protein 1.
    
 
 0.700
taf15
TAF15 RNA polymerase II, TATA box-binding protein (TBP)-associated factor.
   
  
 0.677
h2az2b
Histone H2A; Belongs to the histone H2A family.
   
   0.671
seta
SET translocation (Myeloid leukemia-associated) A; Belongs to the nucleosome assembly protein (NAP) family.
   
 
 0.669
h2az2a
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...]
   
   0.669
ino80
INO80 complex ATPase subunit.
    
 
 0.650
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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