Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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hs6st2Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis. (468 aa)    
Predicted Functional Partners:
glceb
D-glucuronyl C5-epimerase B; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway.
    
 
 0.859
hs2st1a
Heparan sulfate 2-O-sulfotransferase 1a.
    
 
 0.840
ndst2b
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b.
      
 0.808
ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3.
      
 0.799
glcea
Glucuronic acid epimerase a.
    
 
 0.762
ndst1b
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b.
      
 0.755
sulf1
Sulfatase FP1c.
   
 
 0.738
hs3st2
Sulfotransferase; Belongs to the sulfotransferase 1 family.
      
 0.723
gpc4
Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
     
 0.697
hs6st3a
Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
     
  0.695
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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