Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
sf3b4Splicing factor 3b, subunit 4. (400 aa)    
Predicted Functional Partners:
sf3a2
Splicing factor 3a, subunit 2.
   
 0.999
sf3b6
Splicing factor 3b, subunit 6.
   
 0.999
sf3b2
Splicing factor 3b, subunit 2.
   
 0.999
sf3b5
Splicing factor 3B subunit 5; Belongs to the SF3B5 family.
   
 0.999
phf5a
PHD finger protein 5A.
   
 0.999
sf3b1
Splicing factor 3b, subunit 1.
    
 0.999
ddx42
DEAD (Asp-Glu-Ala-Asp) box helicase 42.
    
  0.999
sf3b3
Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...]
   
 0.999
snrpb
Small nuclear ribonucleoprotein-associated protein.
   
 0.998
snrpa1
Small nuclear ribonucleoprotein polypeptide A.
   
 0.998
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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