STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cse1lExportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). Negatively regulates fluid secretion and plays a role in fluid homeostasis by downregulating cftr activity. (971 aa)    
Predicted Functional Partners:
kpna4
Importin subunit alpha; Belongs to the importin alpha family.
   
 0.972
kpna3
Importin subunit alpha; Belongs to the importin alpha family.
   
 0.972
kpna1
Karyopherin alpha 1 (importin alpha 5).
   
 0.971
xpot
Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. Belongs to the exportin family.
   
  
 0.905
ran
GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...]
   
 
 0.892
adgrd1
Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.892
xpo6
Exportin-6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells; Belongs to the exportin family.
   
 
 0.860
kpnb1
Karyopherin (importin) beta 1.
   
 
 0.828
xpo1b
Exportin 1 (CRM1 homolog, yeast) b.
   
 
 0.805
xpo4
Exportin-4; Mediates the nuclear export of proteins (cargos) with broad substrate specificity; Belongs to the exportin family.
   
  
 0.782
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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