STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmx2bThioredoxin-related transmembrane protein 2-B. (307 aa)    
Predicted Functional Partners:
elf2a
E74-like factor 2a (ets domain transcription factor).
   
  
 0.636
C13H9orf72
Zgc:100846.
      
 0.588
supt4h1
Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity).
      
 0.584
agxta
Serine--pyruvate aminotransferase.
      
 0.568
nr1d4b
Nuclear receptor subfamily 1, group D, member 4b.
      
 0.556
ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A4; Belongs to the UDP-glycosyltransferase family.
      
 0.540
gstr
Rho-class glutathione S-transferase; Belongs to the GST superfamily.
      
 0.523
tefb
TEF transcription factor, PAR bZIP family member b.
   
  
 0.488
smcr8a
Guanine nucleotide exchange protein smcr8a; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
   
  
 0.481
tmx1
Thioredoxin-related transmembrane protein 1.
   
 
 0.475
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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