Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mdh1aaMalate dehydrogenase. (333 aa)    
Predicted Functional Partners:
mdh2
Malate dehydrogenase.
   
 0.994
cs
Citrate synthase, mitochondrial.
  
 0.994
got1
Aspartate aminotransferase.
   
 0.985
got2a
Aspartate aminotransferase.
   
 0.983
got1l1
Glutamic-oxaloacetic transaminase 1-like 1.
   
 0.977
me3
Malic enzyme.
  
 0.975
me1
Malic enzyme.
  
 0.975
me2
Malic enzyme.
  
 0.975
pck1
Phosphoenolpyruvate carboxykinase 1 (soluble).
  
 
 0.970
glud1b
Glutamate dehydrogenase 1b; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.970
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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