Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sox21bTranscription factor Sox-21-B; Acts as a negative regulator of transcription. (245 aa)    
Predicted Functional Partners:
sox4a-2
SRY-box transcription factor 4a.
      
 0.719
sall1b
Spalt-like transcription factor 1b.
   
 
 0.654
pou3f3a
POU domain, class 3, transcription factor 3-A; Transcription factor that may play important roles in patterning the embryonic brain.
   
 
 0.599
her3
Hairy-related 3.
      
 0.585
naif1
Nuclear apoptosis-inducing factor 1.
    
   0.551
prox2
Prospero homeobox 2.
   
  
 0.486
rab27b
RAB27B, member RAS oncogene family.
   
 
 0.483
rab11bb
RAB11B, member RAS oncogene family, b.
    
 
 0.473
rab8a
RAB8A, member RAS oncogene family.
    
 
 0.471
ube2ia
SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family.
    
   0.463
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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