Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
twf2bTwinfilin actin-binding protein 2b. (364 aa)    
Predicted Functional Partners:
wdr82
WD repeat-containing protein 82; Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus; Belongs to the WD repeat SWD2 family.
 
      0.894
capzb
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 
 0.833
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4.
      
 0.799
mcf2lb
Mcf.2 cell line-derived-transforming sequence-like b.
      
 0.780
fhdc1
FH2 domain-containing 1.
    
 
 0.780
cfl2
Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.
    
 
 0.738
cfl1
Muscle cofilin 2; Belongs to the actin-binding proteins ADF family.
    
 
 0.731
X1WCU6_DANRE
Profilin; Belongs to the profilin family.
    
 
 0.723
cfl1l
Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family.
    
 
 0.722
gmfb
Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily.
   
 
 0.701
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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