Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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osr1Protein odd-skipped-related 1; Transcriptional repressor (By similarity). Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification. Belongs to the Odd C2H2-type zinc-finger protein family. (264 aa)    
Predicted Functional Partners:
wnk1a
WNK lysine deficient protein kinase 1a.
    
 
 0.669
lhx1a
LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation.
    
 0.569
six1a
Homeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family.
    
 
 0.560
pax8
Paired box 8.
    
 
 0.502
sox32
SRY-box transcription factor 32.
    
 
 0.499
six2a
Sine oculis homeobox homolog 2.1.
   
 
 0.496
pax2a
Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
    
 
 0.488
eya2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.475
vhl
Von Hippel-Lindau tumor suppressor.
    
   0.467
vhll
Von Hippel-Lindau tumor suppressor-like.
    
   0.467
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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