STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dbx1aHomeobox protein DBX1-A; Belongs to the H2.0 homeobox family. (314 aa)    
Predicted Functional Partners:
lhx5
LIM/homeobox protein Lhx5; Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon.
   
 
 0.631
irx3a
Iroquois 3 homeobox protein.
   
 
 0.506
lhx1b
LIM class homeodomain protein.
   
 
 0.502
pax3b
Paired box 3b.
      
 0.490
prdm12b
PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily.
   
  
 0.475
irx1b
Iroquois homeobox protein 1, b.
   
 
 0.473
olig2
Oligodendrocyte lineage transcription factor 2.
   
  
 0.457
elavl3
ELAV-like protein; Belongs to the RRM elav family.
   
  
 0.456
nkx6.1
NK6 homeobox 1.
   
 
0.454
shha
Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
   
  
 0.453
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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