Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
itgb3bIntegrin beta; Belongs to the integrin beta chain family. (790 aa)    
Predicted Functional Partners:
itgav
Integrin, alpha V; Belongs to the integrin alpha chain family.
   
 0.997
itga2b
Integrin, alpha 2b (Platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); Belongs to the integrin alpha chain family.
   
 0.994
itga8
Integrin, alpha 8; Belongs to the integrin alpha chain family.
   
 0.990
itga5
Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family.
   
 0.987
itgb5
Integrin beta; Belongs to the integrin beta chain family.
  
  
0.986
tln1
Talin 1.
   
 0.983
itgb8
Integrin beta; Belongs to the integrin beta chain family.
  
  
0.973
vtnb
Vitronectin b.
    
 0.970
src
Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...]
    
 0.966
vwf
Von Willebrand factor.
   
 0.957
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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