Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
insraTyrosine-protein kinase receptor. (1353 aa)    
Predicted Functional Partners:
irs1
Insulin receptor substrate 1.
   
 0.998
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.997
insb
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.995
irs2b
Insulin receptor substrate 2b.
    
 0.989
irs4a
Insulin receptor substrate 4a.
    
 0.986
ptpn1
Protein tyrosine phosphatase non-receptor type 1.
    
 0.985
shc1
SHC (Src homology 2 domain-containing)-transforming protein 1.
    
 0.978
SHC3
SHC adaptor protein 3.
    
 0.978
irs2a
Insulin receptor substrate 2a.
   
 0.977
grb2b
Growth factor receptor-bound protein 2b.
    
 0.977
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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