Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
zic5ZIC family member 5 (Odd-paired homolog, Drosophila). (497 aa)    
Predicted Functional Partners:
gsx2
GS homeobox 2.
    
 
 0.505
gpr184
G protein-coupled receptor 184; Belongs to the G-protein coupled receptor 1 family.
      
 0.470
sox2
Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
   
 
 0.466
foxg1a
Forkhead box G1a.
   
 
 0.464
rag1
V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...]
   
 0.463
synpo2la
Synaptopodin 2-like a.
    
 
 0.444
bod1
Biorientation of chromosomes in cell division 1.
      
 0.444
c16h2orf66
Uncharacterized protein.
      
 0.418
ttc29
Tetratricopeptide repeat domain 29.
      
 0.411
nfxl1
Nuclear transcription factor, X-box-binding-like 1.
      
 0.411
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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