| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| smad1 | smad2 | ENSDARP00000030150 | ENSDARP00000106756 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | 0.976 |
| smad1 | smad3a | ENSDARP00000030150 | ENSDARP00000045373 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog. | 0.975 |
| smad1 | smad3b | ENSDARP00000030150 | ENSDARP00000043454 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog. | 0.975 |
| smad1 | smad5 | ENSDARP00000030150 | ENSDARP00000054174 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. | 0.994 |
| smad1 | smad6a | ENSDARP00000030150 | ENSDARP00000112408 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog. | 0.993 |
| smad1 | smad6b | ENSDARP00000030150 | ENSDARP00000091342 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog. | 0.991 |
| smad1 | smad7 | ENSDARP00000030150 | ENSDARP00000024277 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog. | 0.997 |
| smad1 | smad9 | ENSDARP00000030150 | ENSDARP00000131023 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | Mothers against decapentaplegic homolog. | 0.994 |
| smad1 | smurf1 | ENSDARP00000030150 | ENSDARP00000003721 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | E3 ubiquitin-protein ligase. | 0.822 |
| smad1 | smurf2 | ENSDARP00000030150 | ENSDARP00000055490 | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. | 0.766 |
| smad2 | smad1 | ENSDARP00000106756 | ENSDARP00000030150 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. | 0.976 |
| smad2 | smad3a | ENSDARP00000106756 | ENSDARP00000045373 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog. | 0.990 |
| smad2 | smad3b | ENSDARP00000106756 | ENSDARP00000043454 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog. | 0.982 |
| smad2 | smad5 | ENSDARP00000106756 | ENSDARP00000054174 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. | 0.976 |
| smad2 | smad6a | ENSDARP00000106756 | ENSDARP00000112408 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog. | 0.992 |
| smad2 | smad6b | ENSDARP00000106756 | ENSDARP00000091342 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog. | 0.990 |
| smad2 | smad7 | ENSDARP00000106756 | ENSDARP00000024277 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog. | 0.993 |
| smad2 | smad9 | ENSDARP00000106756 | ENSDARP00000131023 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | Mothers against decapentaplegic homolog. | 0.976 |
| smad2 | smurf1 | ENSDARP00000106756 | ENSDARP00000003721 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | E3 ubiquitin-protein ligase. | 0.752 |
| smad2 | smurf2 | ENSDARP00000106756 | ENSDARP00000055490 | Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. | 0.980 |
