| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B8JHX5_DANRE | msx3 | ENSDARP00000119466 | ENSDARP00000024644 | Si:ch211-263k4.2. | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.598 |
| arhgef25b | megf6a | ENSDARP00000124252 | ENSDARP00000122302 | Rho guanine nucleotide exchange factor (GEF) 25b. | Multiple EGF-like-domains 6a. | 0.818 |
| arhgef25b | msx3 | ENSDARP00000124252 | ENSDARP00000024644 | Rho guanine nucleotide exchange factor (GEF) 25b. | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.500 |
| fgf20a | fgfr1a | ENSDARP00000007295 | ENSDARP00000013742 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.974 |
| fgf20a | msx1a | ENSDARP00000007295 | ENSDARP00000147264 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Muscle segment homeobox 1a. | 0.469 |
| fgf20a | msx2b | ENSDARP00000007295 | ENSDARP00000140454 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Homeobox protein MSH-D; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.619 |
| fgf20a | msx3 | ENSDARP00000007295 | ENSDARP00000024644 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.662 |
| fgf20a | shha | ENSDARP00000007295 | ENSDARP00000125090 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.513 |
| fgfr1a | fgf20a | ENSDARP00000013742 | ENSDARP00000007295 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.974 |
| fgfr1a | msx1a | ENSDARP00000013742 | ENSDARP00000147264 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Muscle segment homeobox 1a. | 0.529 |
| fgfr1a | msx3 | ENSDARP00000013742 | ENSDARP00000024644 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.448 |
| fgfr1a | shha | ENSDARP00000013742 | ENSDARP00000125090 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.718 |
| megf6a | arhgef25b | ENSDARP00000122302 | ENSDARP00000124252 | Multiple EGF-like-domains 6a. | Rho guanine nucleotide exchange factor (GEF) 25b. | 0.818 |
| megf6a | msx3 | ENSDARP00000122302 | ENSDARP00000024644 | Multiple EGF-like-domains 6a. | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.444 |
| msx1a | fgf20a | ENSDARP00000147264 | ENSDARP00000007295 | Muscle segment homeobox 1a. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.469 |
| msx1a | fgfr1a | ENSDARP00000147264 | ENSDARP00000013742 | Muscle segment homeobox 1a. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.529 |
| msx1a | msx2a | ENSDARP00000147264 | ENSDARP00000132799 | Muscle segment homeobox 1a. | Homeobox protein MSH-A; Probable morphogenetic role; Belongs to the Msh homeobox family. | 0.961 |
| msx1a | msx2b | ENSDARP00000147264 | ENSDARP00000140454 | Muscle segment homeobox 1a. | Homeobox protein MSH-D; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.961 |
| msx1a | msx3 | ENSDARP00000147264 | ENSDARP00000024644 | Muscle segment homeobox 1a. | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. | 0.872 |
| msx1a | shha | ENSDARP00000147264 | ENSDARP00000125090 | Muscle segment homeobox 1a. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.794 |
