Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ctnsCystinosin, lysosomal cystine transporter. (384 aa)    
Predicted Functional Partners:
slc66a1
Solute carrier family 66 member 1.
   
 
 0.902
shpk
Sedoheptulokinase.
      
 0.826
mfsd12a
Major facilitator superfamily domain-containing 12a.
   
  
 0.761
lrp2a
Low density lipoprotein receptor-related protein 2a.
      
 0.758
clcn5b
Chloride channel, voltage-sensitive 5b; Belongs to the chloride channel (TC 2.A.49) family.
      
 0.734
lamp1b
Lysosomal-associated membrane protein 1b.
      
 0.645
slc17a5
Solute carrier family 17 member 5.
      
 0.639
pi4k2b
Phosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity).
   
  
 0.614
pi4k2a
Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
   
  
 0.614
lamp1a
Lysosomal-associated membrane protein 1a.
      
 0.612
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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