Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
creb3l3lcAMP-responsive element-binding protein 3-like 3 like. (503 aa)    
Predicted Functional Partners:
rps6ka5
Ribosomal protein S6 kinase.
    
  0.951
creb3l1
cAMP-responsive element-binding protein 3-like 1.
    
0.946
creb3l2
Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...]
   
0.946
creb3l3a
Processed cyclic AMP-responsive element-binding protein 3-like protein 3-B; Transcriptional activator. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with atf6 (By similarity).
    
 0.944
creb5b
Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.
    
 0.937
atf6
Activating transcription factor 6.
    
 0.932
creb3l3b
Cyclic AMP-responsive element-binding protein 3-like protein 3-B.
    
 0.932
atf4a
Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity).
     
 0.929
ppargc1a
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
    
 0.917
htt
Huntingtin.
     
 0.913
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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