Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mark3aNon-specific serine/threonine protein kinase. (722 aa)    
Predicted Functional Partners:
LOC110440168
EWS RNA-binding protein 1b.
      
 0.720
ewsr1b
Ewing sarcoma breakpoint region 1b.
      
 0.662
mtcl1
Microtubule crosslinking factor 1.
    
 
 0.635
ppp1r12c
Protein phosphatase 1, regulatory subunit 12C.
   
 
 0.615
cmtr1
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
   
  
 0.611
ctdspl2b
CTD small phosphatase-like protein 2-B; Probable phosphatase.
    
 
 0.597
TOM1L2
Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family.
      
 0.565
tom1l2
Target of myb1-like 2 membrane-trafficking protein; Belongs to the TOM1 family.
      
 0.565
ywhae2
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.
    
 
 0.523
ywhae1
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family.
    
 
 0.523
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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