STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trim33E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa)    
Predicted Functional Partners:
smad4a
Mothers against decapentaplegic homolog.
   
 0.905
gata1a
GATA-binding protein 1a.
   
 
 0.876
smad2
Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis.
   
 0.847
smad3a
Mothers against decapentaplegic homolog.
   
 0.729
myb
V-myb avian myeloblastosis viral oncogene homolog.
   
 
 0.718
spi1b
SI:bY184L24.2.1 (Transcription factor spi1).
   
 
 0.680
cdc27
Cell division cycle 27.
   
   0.643
anapc1
Anaphase-promoting complex subunit 1.
   
   0.641
anapc4
Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.
    
   0.637
cdc23
CDC23 (Cell division cycle 23, yeast, homolog).
   
   0.637
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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