Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
zfp36l1aZinc finger protein 36, C3H type-like 1a. (374 aa)    
Predicted Functional Partners:
mapkapk2a
Mitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily.
    
 0.977
xrn1
5'-3' exoribonuclease 1.
   
 0.871
zfp36l2
Zinc finger protein 36, C3H type-like 2.
     
  0.864
mapkapk2b
MAPK-activated protein kinase 2b; Belongs to the protein kinase superfamily.
    
 0.862
cnot1
CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRN [...]
    
 
 0.826
cnot6l
CCR4-NOT transcription complex subunit 6-like; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).
    
 
 0.785
btg4
B-cell translocation protein 4a.
   
  
 0.780
akt3b
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
  0.778
exosc8
Exosome component 8.
    
  0.769
dcp2
DCP2 decapping enzyme homolog (S. cerevisiae).
   
 0.768
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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